Multi-Dimensional Microscopy to Probe Osseointegration and Biomineralization
Apr 29, 2022
2:30PM to 3:30PM
Date(s) - 29/04/2022
2:30 pm - 3:30 pm
Uncovering the mechanisms of biomineralization or biomaterial-tissue interactions is complicated by the complex and three-dimensional hierarchical structure of human bone. Our work explores the structure and formation of bone and its attachment to biomaterials with advanced microscopy approaches. This talk will introduce a range of correlative, 3D, and real-time high-resolution approaches to probe both biomineralization and osseointegration including electron tomography, focused ion beam microscopy, and atom probe tomography. These correlative microscopies provide a foundation for understanding the structure and chemical nature of inorganic and organic hierarchical materials, including shedding light on the titanium-bone interface, collagen-mineral arrangement, and new approaches for visualizing osteocyte networks and mineral clustering in bone.
Kathryn Grandfield is an Associate Professor in the Department of Materials Science & Engineering and School of Biomedical Engineering at McMaster University. She holds the Canada Research Chair in Microscopy of Biomaterials and Biointerfaces. Dr. Grandfield received her B.Eng. and M.A.Sc. in Materials Science and Engineering from McMaster University, and her PhD in Engineering Sciences from Uppsala University. She completed a postdoctoral fellowship in the Department of Preventative and Restorative Dental Sciences at the University of California, San Francisco. She is the recipient of several awards including the 2017 Petro Canada Young Innovator Award, the 2018 Early Researcher Award from the Ontario Ministry of Research, Science and Innovation, and the 2019 McMaster Faculty of Engineering Teaching Excellence Award. She is currently the President of the Microscopical Society of Canada.